| 摘要 |
PROBLEM TO BE SOLVED: To provide methods for modulating the release and/or drug-loading characteristics of an encapsulated bioactive agent through direct modification of the bioactive agent itself, and compositions containing the same.SOLUTION: Modification of the isoelectric point of a bioactive agent such as a peptide molecule, e.g., alteration of the overall charge of the peptide, can predictably modify the release and/or loading characteristics of polymer-based delivery systems in clinically meaningful ways including, e.g., reducing or enhancing the initial diffusional release of the peptide from the polymer-based delivery system, modulating the erosional release rate from biodegradable systems, and/or increasing the encapsulation efficiency of such peptides. |
