| 摘要 |
The present invention is directed to the identification of modulators for SLC22A13 transporter, function of SLC22A13 and therapeutic uses thereof. Hence, in one embodiment the present invention relates to a method for identifying and/or obtaining a compound capable of modulating SLC22A13 transport activity, comprising contacting a test compound with a system for measuring those transport activity, which system comprises an SLC22A13 polypeptide or a functional fragment thereof, and a substrate for measuring transport activity by the system; and detecting an altered level of the those transport activity of the SLC22A13 polypeptide or functional fragment in the presence of the test compound compared to the described transport activity in the absence of the test compound and/or presence of a control. |
