发明名称 |
Device, Array, And Methods For Disease Detection And Analysis |
摘要 |
A device and array coupled to capture molecules are provided. Specifically, the device and array can be used for detecting the presence and concentration of biomarkers in a sample from a subject. The device and array can also allow the use of a method for scoring a sample for, e.g., the purpose of diagnosing a disease. The method can also be advantageous to applications where there is a need to accurately determine the disease stage of a subject for the purpose of making therapeutic decisions. |
申请公布号 |
US2015087543(A1) |
申请公布日期 |
2015.03.26 |
申请号 |
US201414465796 |
申请日期 |
2014.08.21 |
申请人 |
Rao Rupa S.;Lane Stephen M.;Matthews Dennis L.;Coleman Matthew A. |
发明人 |
Rao Rupa S.;Lane Stephen M.;Matthews Dennis L.;Coleman Matthew A. |
分类号 |
G01N33/543;B01J19/00 |
主分类号 |
G01N33/543 |
代理机构 |
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代理人 |
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主权项 |
1. A multiplex immunoassay detection device for measurement of breast cancer markers in a patient sample, comprising:
a glass solid support comprising a plurality of distinct spots arranged in an array format, each spot comprising a distinct capture antibody capable of binding to a breast cancer marker, the distinct capture antibody selected from the group consisting of antibody Clone 191924 for HER2, antibody Clone 36006.211 for MMP-2, antibody Clone M8071022 for CA-15-3 and antibody Clone 190312 for osteopontin; a glass cover plate, wherein the glass cover plate forms an upper surface positioned above the solid support; a vertical support comprising adhesive silicone, wherein the vertical support forms a connection between the solid support and the cover plate, the connection forming at least one channel surrounding the array of capture antibodies, and wherein the channel comprises a first end and a second end and wherein the first end of the channel comprises an opening; and an absorbent material comprising a nitrocellulose membrane connected to the second end. |
地址 |
Stockton CA US |