发明名称 |
TETRAHYDROISOQUINOLINE COMPOUNDS AND THEIR USE AS PYRUVATE DEHYDROGENASE KINASE INHIBITORS |
摘要 |
<p>A compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein: R1 is H, Cl, F, CH3 or CF3; R2 is H, C1-C6 alkyl or optionally substituted heteroaryl or optionally substituted aryl; and R3 is (Alk)n-Rn-(Alk)n-Rn-(Alk)n-X. The compounds are useful as tetrahydroisoquinoline (THQ) compounds, which are suitable for use as PDK inhibitors, for example for inhibition of cancer cell proliferation.</p> |
申请公布号 |
WO2015040424(A1) |
申请公布日期 |
2015.03.26 |
申请号 |
WO2014GB52875 |
申请日期 |
2014.09.22 |
申请人 |
VERNALIS (R&D) LIMITED |
发明人 |
BROUGH, PAUL ANDREW;MACIAS, ALBA;ROUGHLEY, STEPHEN DAVID;STOKES, STEPHEN;DAVIES, NICHOLAS GARETH MORSE |
分类号 |
C07D215/14;A61K31/47;A61K31/4709;A61P35/00;C07D401/04;C07D401/06;C07D401/12;C07D401/14;C07D405/04;C07D405/12;C07D409/12;C07D409/14;C07D413/14;C07D417/04;C07D487/04 |
主分类号 |
C07D215/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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