| 发明名称 |
RIBONUCLEOTIDE REDUCTASE INHIBITORS AND METHODS OF USE |
| 摘要 |
Provided herein are novel compounds that inhibit ribonucleotide reductase (RR) by binding to RRM2 and interfering with the activity of the RRM1/RRM2 holoenzyme, as well as methods of synthesizing these novel compounds. The compounds may be used to inhibit RR activity and to treat various conditions associated with RRM2 expression, such as for example certain cancer types, mitochondrial diseases, or degenerative diseases. |
| 申请公布号 |
US2015087844(A1) |
申请公布日期 |
2015.03.26 |
| 申请号 |
US201414444172 |
申请日期 |
2014.07.28 |
| 申请人 |
City of Hope |
发明人 |
Horne David;Lincoln Christopher |
| 分类号 |
C07D277/46;C07D277/40;C07C45/68 |
主分类号 |
C07D277/46 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of synthesizing a compound having the structure: comprising the steps: (a) converting veratrole to 1-(3,4-dimethoxyphenyl)-2-phenylethanone; (b) converting 1-(3,4-dimethoxyphenyl)-2-phenylethanone to 4-(3,4-dimethoxyphenyl)-5-phenylthiazol-2-amine; (c) converting 4-(3,4-dimethoxyphenyl)-5-phenylthiazol-2-amine to N-(4-(3,4-dimethoxyphenyl)-5-phenylthiazol-2-yl)-3,4-dimethoxybenzamide; and (d) converting N-(4-(3,4-dimethoxyphenyl)-5-phenylthiazol-2-yl)-3,4-dimethoxybenzamide to |
| 地址 |
Duarte CA US |
