| 发明名称 |
BINDING MOIETIES FOR BIOFILM REMEDIATION |
| 摘要 |
Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies secreted by human B lymphocytes. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described. |
| 申请公布号 |
US2015086561(A1) |
申请公布日期 |
2015.03.26 |
| 申请号 |
US201414497147 |
申请日期 |
2014.09.25 |
| 申请人 |
TRELLIS BIOSCIENCE, LLC |
发明人 |
KAUVAR Lawrence M.;RYSER Stefan;ESTELLES Angeles;STEPHENSON Robert;SIMON Reyna J.;NOURZAIE Omar |
| 分类号 |
C07K16/12;C07K14/285;G01N33/569;A61K39/104;A61K39/108;A61K39/102;C07K7/08;A61K39/085 |
主分类号 |
C07K16/12 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A monoclonal binding moiety that has affinity for at least one DNABII protein that exceeds the affinity of said protein for components of a biofilm that includes said DNABII protein, which is a monoclonal antibody (mAb), an aptamer, a non-Ig scaffold or a structured short peptide. |
| 地址 |
SOUTH SAN FRANCISCO CA US |
