发明名称 |
Use of Survivin Antagonists in Polyomavirus-Related Disease |
摘要 |
A method of treating a polyomavirus (+) cancer in which survivin is upregulated in a patient is provided, comprising administering to the patient a therapeutically effective amount of a composition that downregulates survivin expression or function in cells of the polyomavirus (+) cancer. A method of reducing growth of polyomavirus (+) cancer cells in which survivin is up-regulated is provided, comprising contacting the cells with an amount of a composition that downregulates survivin expression or function effective to reduce growth of the cells. Also provided is sepantronium salt, for use in treating a polyomavirus (+) cancer in which survivin is up-regulated. |
申请公布号 |
US2015086535(A1) |
申请公布日期 |
2015.03.26 |
申请号 |
US201314388418 |
申请日期 |
2013.03.26 |
申请人 |
University of Pittsburgh-of the Commonwealth System Higher Education |
发明人 |
Chang Yuan;Moore Patrick S. |
分类号 |
A61K31/497;A61K45/06 |
主分类号 |
A61K31/497 |
代理机构 |
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代理人 |
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主权项 |
1. A method of treating a polyomavirus (+) cancer in which survivin is upregulated in a patient, comprising administering to the patient a therapeutically effective amount of a composition that downregulates survivin expression or function in cells of the polyomavirus (+) cancer. |
地址 |
Pittsburgh PA US |