| 发明名称 |
OPTIMISED SUBCUTANEOUS THERAPEUTIC AGENTS |
| 摘要 |
Methods and dosage formulations are provided for subcutaneous administration in which therapeutic agents are modified to increase the hydrophilicity and molecular dimensions in relation to the native state of the therapeutic agent, in which the Cmax:Caverage ratio is lower than the Cmax:Caverage ratio of the agent when delivered intravenously. |
| 申请公布号 |
US2015086524(A1) |
申请公布日期 |
2015.03.26 |
| 申请号 |
US201314394437 |
申请日期 |
2013.04.16 |
| 申请人 |
Cantab Biopharmaceuticals Patents Limited |
发明人 |
Henry William;Wolf-Garraway Richard;Mayo John Charles;Earl Michael James |
| 分类号 |
A61K9/00;A61K47/48;A61K38/37;A61K38/48 |
主分类号 |
A61K9/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of administering a therapeutic agent to a patient, comprising subcutaneously administering the therapeutic agent to the patient, such that the Cmax:Caverage ratio is lower than the Cmax:Caverage ratio of the agent when delivered intravenously, and wherein the therapeutic agent is modified in order to increase the hydrophilicity and modify the molecular dimensions in relation to the native state of the therapeutic agent. |
| 地址 |
Valetta MT |
