N1/N2-LACTAM ACETYL-COA CARBOXYLASE INHIBITOR

摘要

PROBLEM TO BE SOLVED: To provide a method for treating obesity and obesity-related diseases (such as non-alcoholic fatty liver disease and type 2 diabetes mellitus) by inhibiting fatty acid synthesis and increasing fatty acid oxidation.SOLUTION: Substituted pyrazolospiroketone having acetyl-CoA carboxylase enzyme (ACC1 and/or ACC2) inhibitory activity, and represented by the following formula, is used for a therapeutic agent of the diseases.