| 主权项 |
1. A process for preparing a quaternary ammonium salt of formula (4):wherein
X is halogen atom, C1-6 alkylsulfonyloxy group, or C6-10 arylsulfonyloxy group, and X− is a counteranion thereof, Y is a substituent of the following formula (2a) or (2b): wherein R1 is independently methylene or oxygen atom; R2 is independently C1-6 alkyl group, C1-6 alkoxy group, or hydroxy group; m and n are independently 0, 1, 2, or 3; and p is 1 or 2, and Z is ═N—R3 or ═CH—R4 wherein R3 is C1-6 alkyl group, cycloalkyl group, C5-7, cycloalkenyl group, C6-10 aryl group, or 5- to 10-membered monocyclic or bicyclic heteroaryl group; R4 is C1-6 alkyl group, C1-6 alkoxy group, C1-6 alkylthio group, C3-7 cycloalkyl group, C3-7 cycloalkyloxy group, C3-7 cycloalkylthio group, C5-7 cycloalkenyl group, C5-7 cycloalkenyloxy group, C5-7 cycloalkenylthio group, C6-10 aryl group, C6-10 aryloxy group, C6-10 arylthio group, 5- to 10-membered monocyclic or bicyclic heteroaryl group, 5- to 10-membered monocyclic or bicyclic heteroaryloxy group, or 5- to 10-membered monocyclic or bicyclic heteroarylthio group, comprising reacting a compound of formula (1):wherein X is independently selected from the above-defined ones, and Y is as defined above,
with 1.5 to 15 mole of a compound of formula (3):wherein Z is as defined above, per one mole of the compound of formula (1)
to prepare the quaternary ammonium salt of formula (4). |
