发明名称 |
COMBINATION OF CD37 ANTIBODIES WITH ICE (IFOSFAMIDE, CARBOPLATIN, ETOPOSIDE) |
摘要 |
The present invention relates to immunotherapies that are based on depletion of CD37-positive cells such as B-cells. The present invention provides methods for reduction of CD37-positive cells such as B-cells in an individual/patient using a combination of CD37 antibody/antibodies and ICE. The combination of CD37 antibodies and ICE is shown to have improved anti-tumor efficacy compared to single agent treatment. The application further provides materials and methods for treatment of diseases involving aberrant B-cell activity. |
申请公布号 |
EP2849784(A1) |
申请公布日期 |
2015.03.25 |
申请号 |
EP20130723498 |
申请日期 |
2013.05.15 |
申请人 |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH |
发明人 |
HEIDER, KARL-HEINZ;BAUM, ANKE;RUSSELL, CHARLOTTE ASTRID |
分类号 |
A61K39/395;A61P35/02;C07K16/28 |
主分类号 |
A61K39/395 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|