Immunogenic compositions comprising a gp120 related polypeptide

摘要

The present invention relates to particular immunogenic compositions comprising a gpl2O related polypeptide and an adjuvant, wherein the adjuvant comprises a saponin and a lipopolysaccharide. Such compositions are substantially free of a NefTat related polypeptide, comprise between 1O-4Oug of a lipopolysaccharide and between 1O-4Oug of an immunologically active saponin fraction derived from the bark of Quillaja Saponaria Molina presented in the form of a liposome or have a concentration of sodium chloride of 130 mM or lower.