Serpins: methods of therapeutic ß-cell regeneration and function

摘要

Compositions and methods of use are provided for improving ² cell function and promoting pancreatic ² cell proliferation in vitro, in vivo and ex vivo. The active agents of the pending invention comprise Serpin family peptides (e.g., SerpinB1), functional and structural analogs of Serpin family peptides and nucleic acids encoding Serpin family peptides, as well as active fragments thereof.