发明名称 |
REAGENTS, METHODS AND SYSTEMS FOR SELECTING A CYTOTOXIC ANTIBODY OR VARIANT THEREOF |
摘要 |
<p>The present invention provides reagents, methods and systems for predicting the cytotoxic activity of an antibody or variant thereof comprising: determining a binding affinity of the antibody or variant thereof to a Fc activating receptor; determining a binding affinity of the antibody or variant thereof to a Fc inhibitory receptor, and calculating the ratio of said activating binding affinity to said inhibitory binding affinity (A/I ratio), wherein the magnitude of said ratio is an indication of the cytotoxic activity of the antibody or variant thereof . The present invention also provides purified modified antibodies having altered A/I ratios as compared to the unmodified antibodies.</p> |
申请公布号 |
EP1957099(B1) |
申请公布日期 |
2015.03.25 |
申请号 |
EP20060826738 |
申请日期 |
2006.10.27 |
申请人 |
THE ROCKEFELLER UNIVERSITY |
发明人 |
RAVETCH, JEFFREY;NIMMERJAHN, FALK |
分类号 |
A61K39/00;A61K39/395;G01N33/53 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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