COMPOSITIONS AND METHODS FOR MODULATING PTEN EXPRESSION
摘要
<p>Aspects of the invention provide single stranded oligonucleotides for activating or enhancing expression of PTEN. Further aspects provide compositions and kits comprising single stranded oligonucleotides for activating or enhancing expression of PTEN. Methods for modulating expression of PTEN using the single stranded oligonucleotides are also provided. Further aspects of the invention provide methods for selecting a candidate oligonucleotide for activating or enhancing expression of PTEN.</p>
申请公布号
EP2850187(A1)
申请公布日期
2015.03.25
申请号
EP20130790838
申请日期
2013.05.16
申请人
RANA THERAPEUTICS INC.;THE GENERAL HOSPITAL CORPORATION D/B/A MASSACHUSETTS GENERAL HOSPITAL
发明人
KRIEG, ARTHUR, M.;SUBRAMANIAN, ROMESH;MCSWIGGEN, JAMES;LEE, JEANNIE, T.