发明名称 |
AMINOPYRAZINE COMPOUNDS USEFUL AS INHIBITORS OF TRA KINASE |
摘要 |
The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: wherein the variables are as defined herein. |
申请公布号 |
ZA201307332(B) |
申请公布日期 |
2015.03.25 |
申请号 |
ZA20130007332 |
申请日期 |
2013.10.01 |
申请人 |
VERTEX PHARMACEUTICAL INCORPORATED |
发明人 |
CHARRIER JEAN-DAMIEN;MACCORMICK SOMHAIRLE;STORCK PIERRE-HENRI;PINDER JOANNE;O'DONNELL MICHAEL EDWARD;KNEGTEL RONALD MARCELLUS ALPHONSUS;YOUNG STEPHEN CLINTON YOUNG;KAY DAVID;REAPER PHILIP MICHAEL;DURRANT STEVEN JOHN;TWIN HEATHER CLARE;DAVIS CHRISTOPHER JOHN |
分类号 |
C07D;A61K;A61P |
主分类号 |
C07D |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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