Sulodexide for use in the treatment of pathologies wherein metalloproteinases are involved

摘要

The present invention describes sulodexide or at least one of its components for use in the reduction of circulating matrix metalloproteinase (MMPs), in particular MMP-9. Sulodexide and its composition are useful for the treatment of pathologies wherein the MMPs are involved, such as cardiovascular disease, cardiovascular disease caused by diabetes, varicose veins, chronic venous insufficiency (CVI), gastrointestinal ulcers, pulmonary disease, and neoplastic pathologies.

主权项

1. A method to treat a patient, the method comprising:
administering to the patient a sulodexide extracted component dermatan sulfate and/or low molecular weight heparin, or a mixture thereof, or a pharmaceutically acceptable salt, solvate, hydrate, clathrate thereof to treat a pathology involving matrix metalloproteinases (MMPs).