摘要 |
<p>An object of the present invention is to provide a STAT3/5 activation inhibitor. The present invention provides a STAT3/5 activation inhibitor containing an aromatic compound represented by the general formula or a salt thereof as an active ingredient: wherein X1 represents a nitrogen atom or a group -CH=, R1 represents a group -Z-R6, in which Z represents a group -CO-, a group -CH(OH)- or the like, R6 represents a 5-to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R2 represents a hydrogen atom or a halogen atom, Y represents a group -O-, a group -CO-, a group -CH(OH)-or a lower alkylene group, and A represents a group wherein R3 represents a hydrogen atom, a lower alkoxy group or the like, p represents 1 or 2, R4 represents an imidazolyl lower alkyl group or the like.</p> |
申请人 |
OTSUKA PHARMACEUTICAL CO., LTD. |
发明人 |
SEKIGUCHI, KAZUO;SUZUKI, TAKASHI;OHBUCHI, YUTAKA;OKUNO, MITSUHIRO;OHI, NAOTO;OHNISHI, KENJI;MOTOYAMA, MASAAKI;YOSHIDA, KENJI;KODAMA, TAKESHI;SUGIYAMA, KAZUHISA;AKAMATSU, SEIJI;KIYONO, KUNIHIKO;YANAGIHARA, YASUO;WATANABE, TAKASHI;HAYASHI, KAZUHIKO;TANAKA, HIDEO;SUMIDA, TAKUMI |