发明名称 |
Anticorpo isolado que se liga de forma seletiva ao peptídeo beta-amilóide, composição farmacêutica compreendendo o referido anticorpo, sequência de ácido nucléico, vetor e célula hospedeira |
摘要 |
<p>The invention discloses an isolated antibody that selectively binds to the C-terminal part of Abeta and is humanized or fully human. The antibody of the invention is capable of preventing oligomerization of Abeta. Furthermore, a method of diagnosis comprising the steps of: (i) Labelling an antibody; (ii) Administering an effective dose of said antibody intranasally or systemically to a subject; and (iii) Detecting the concentration and/or presence of the labelled antibody in body parts of the subject is disclosed.</p> |
申请公布号 |
BRPI0817099(A2) |
申请公布日期 |
2015.03.24 |
申请号 |
BR2008PI17099 |
申请日期 |
2008.09.15 |
申请人 |
DELENEX THERAPEUTICS AG;UNIVERSITY ZÜRICH |
发明人 |
STEFAN EWERT;ADRIAN AUF DER MAUR;SUSAN CATTEPOEL;ROGER NITSCH |
分类号 |
C07K16/18;A61K39/395;A61P25/28;G01N33/53 |
主分类号 |
C07K16/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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