| 发明名称 | AMPK-activating heterocyclic compounds and methods for using the same | ||
| 摘要 | Disclosed are substituted pyridine compounds as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure;wherein E, J, T, the ring system denoted by “B”, T, R3, R4, w and x are as described herein. In certain embodiments, a compound disclosed herein activates the AMPK pathway, and can be used to treat metabolism-related disorders and conditions. | ||
| 申请公布号 | US8987303(B2) | 申请公布日期 | 2015.03.24 |
| 申请号 | US201313801030 | 申请日期 | 2013.03.13 |
| 申请人 | Rigel Pharmaceuticals, Inc. | 发明人 | Goff Dane;Payan Donald;Singh Rajinder;Shaw Simon;Carroll David;Hitoshi Yasumichi |
| 分类号 | A61K31/4427;C07D401/14;C07D487/04;C07D213/82;C07D401/06;C07D401/12;C07D405/14;C07D409/12;C07D409/14;C07D413/14;C07D417/14;C07D451/06;C07D471/10;C07D495/04;C07D405/12;C07D213/81;C07D213/56 | 主分类号 | A61K31/4427 |
| 代理机构 | McDonnell Boehnen Hulbert & Berghoff LLP | 代理人 | McDonnell Boehnen Hulbert & Berghoff LLP ;Young Travis |
| 主权项 | 1. N-((trans)-1-(4-cyanobenzyl)-3-fluoropiperidin-4-yl)-6-(4-(4-methoxybenzoyl)piperidine-1-carbonyl)nicotinamide or a pharmaceutically acceptable salt or N-oxide thereof. | ||
| 地址 | South San Francisco CA US | ||