Nisin derivatives and the use thereof

摘要

The present invention relates to a nisin derivative comprising amino acid substitutions in the peptide sequence encoding the hinge region of the protein, wherein the derivative exhibits an increased anti-microbial activity.

主权项

1. A nisin derivative, comprising at least one amino acid substitution in a peptide sequence encoding a hinge region of nisin protein, the hinge region being identified as positions 20, 21, and 22 of SEQ ID NO:1, wherein the substitution results in a proline, serine, glycine, alanine, histidine, glutamine, phenylalanine, arginine or a threonine at amino acid position 20 of SEQ ID NO:1, an alanine, valine, threonine, leucine, isoleucine, methionine, asparagine, glycine, serine, or histidine at amino acid position 21 of SEQ ID NO:1, or a threonine, lysine, valine, serine, alanine, leucine, methionine, glutamine, arginine, glycine, cysteine, or histidine, at amino acid position 22 of SEQ ID NO:1, and wherein the derivative exhibits an increased anti-microbial activity.