Transcutaneous analyte sensor

摘要

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

主权项

1. A glucose sensor for measuring a glucose concentration in a host, the sensor comprising:
a first electrode comprising a first electroactive portion, wherein the first electrode is a working electrode; a second electrode comprising a second electroactive portion, wherein the second electrode is a reference electrode, wherein the second electrode is not in contact with a first domain; a membrane system located over at least one of the first electroactive portion or the second electroactive portion, the membrane system comprising:
the first domain comprising an enzyme;a second domain, wherein the second domain is configured to control a flux of glucose and oxygen therethrough; anda third domain comprising a biointerface, wherein the third domain is configured to inhibit cell migration towards at least one of the first electroactive portion or the second electroactive portion; wherein the sensor comprises an ex vivo portion and an in vivo portion, wherein the ex vivo portion is configured to reside outside a body of the host during glucose sensing, wherein the in vivo portion is configured to be in contact with host tissue during glucose sensing and measure a glucose concentration within the host tissue for a time period, and wherein the time period is from about one day to about 14 days.