3-pyridyl carboxamide-containing spleen tyrosine kinase (SYK) inhibitors

摘要

The invention provides certain 3-pyridyl carboxamide-containing compounds of the Formula (I) (I) or pharmaceutically acceptable salts thereof, wherein A and B are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk) kinase.;

主权项

1. A compound of the Formula (I) or a pharmaceutically acceptable salt thereof, wherein B is pyridyl or quinolinyl;
wherein B is unsubstituted or substituted by 1 to 3 R3 moieties, wherein each R3 moiety is independently selected from the group consisting of C1-C3 alkyl, C1-C3 alkoxy, C1-C3 fluoroalkyl, C1-C3 hydroxyalkyl, halo, hydroxy, amino, (C1-C3 alkyl)amino, di(C1-C3 alkyl)amino, and E;
wherein E is a 5-membered heteroaryl containing 1 to 3 N atoms, wherein E is unsubstituted or substituted by 1 to 2 moieties independently selected from the group consisting of C1-C3 alkyl; A is selected from the group consisting of: wherein
Y is —CH2— or —O—;R11 and R12 are independently H or F; andn′ is 0 or 1; and wherein
Ra and Rb are independently H or C1-C6 alkyl;Rc is H, C1-C6 alkyl, C1-C3 fluoroalkyl, C3-C6 cycloalkyl, or —(CH2)rOR13,
wherein R13 is H or C1-C3 alkyl; andr is 1 or 2;Rd is H or C1-C6 alkyl,or Re and Rd together with the carbon atom to which they are attached form a group of the formula wherein p is 1 or 2.