发明名称 Biocompatible polyacrylate compositions for medical applications
摘要 A composition comprising a structural component comprising linear acrylic homopolymers or linear acrylic copolymers and a biobeneficial component comprising copolymers having an acrylate moiety and a biobeneficial moiety is disclosed. A medical article comprising the composition in the coating thereof and a method of fabricating the medical article are also disclosed.
申请公布号 US8986726(B2) 申请公布日期 2015.03.24
申请号 US201313911547 申请日期 2013.06.06
申请人 Abbott Cardiovascular Systems Inc. 发明人 Hossainy Syed F. A.
分类号 A61F2/00;A61L31/16;A61K31/74;A61K31/445;A61L31/10 主分类号 A61F2/00
代理机构 Squire Patton Boggs (US) LLP 代理人 Squire Patton Boggs (US) LLP
主权项 1. A composition comprising: (a) a biologically compatible structural component comprising a linear acrylic homopolymer or a linear acrylic copolymer; and (b) a biobeneficial component comprising a copolymer having an acrylate moiety and a biobeneficial moiety;wherein the copolymer composing the biobeneficial component has the formula: wherein (a) m1, n1, p1, r1, m2, n2, p2, and r2 are all integers; (b) m1≧0, n1>0, p1≧0, r1>0; m2≧0, n2>0, p2≧0, r2>0; and (c) (i) if m1=0, then p1>0;(ii) if p1=0, then m1>0; and(iii) if m2=0, then p2 >0; and(iv) if p2=0, then m2>0; and(v) r1 and r2 are the same or different;(vi) m1 and m2 are the same or different;(vii) n1 and n2 are the same or different; and(viii) p1 and p2 are the same or different; (d) X is hydrogen or methyl group; (e) each of R, R1 and R2, independently, is methyl, ethyl, n-propyl, iso-propyl, n-butyl, sec-butyl, iso-butyl, tert-butyl, lauryl, or 2-hydroxyethyl; and (f) Q is a fragment providing the copolymer with biobeneficial or bioactive properties.
地址 Santa Clara CA US