| 发明名称 | Mutant fragments of OspA and methods and uses relating thereto | ||
| 摘要 | The present invention relates to a polypeptide comprising a mutant fragment of an outer surface protein A (OspA), a nucleic acid coding the same, a pharmaceutical composition (particularly for use as a medicament of in a method of treating or preventing a Borrelia infection) comprising the polypeptide and/or the nucleic acid, a method of treating or preventing a Borrelia infection and a method of immunizing a subject. | ||
| 申请公布号 | US8986704(B2) | 申请公布日期 | 2015.03.24 |
| 申请号 | US201313802991 | 申请日期 | 2013.03.14 |
| 申请人 | Valneva Austria GmbH | 发明人 | Comstedt Pär;Hanner Markus;Lundberg Urban;Meinke Andreas;Schueler Wolfgang;Wizel Benjamin |
| 分类号 | A61K39/02;A61K38/00;C12N15/00;C07K14/195;C07K14/20;C12N5/07;C12N15/70 | 主分类号 | A61K39/02 |
| 代理机构 | Wolf, Greenfield & Sacks, P.C. | 代理人 | Wolf, Greenfield & Sacks, P.C. |
| 主权项 | 1. A polypeptide comprising a mutant OspA fragment heterodimer selected from the group consisting of Lip-S1D1-S2D1 (SEQ ID NO: 186), Lip-S2D1-S1D1 (SEQ ID NO: 192), Lip-S1D1-S2D4 (SEQ ID NO: 198), and Lip-S2D4-S1D1 (SEQ ID NO: 203). | ||
| 地址 | Vienna AT | ||