发明名称 |
Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of threonyl-tRNA synthetases |
摘要 |
Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications. |
申请公布号 |
US8986681(B2) |
申请公布日期 |
2015.03.24 |
申请号 |
US201113643750 |
申请日期 |
2011.04.27 |
申请人 |
aTyr Pharma, Inc.;Pangu BioPharma Limited |
发明人 |
Greene Leslie Ann;Chiang Kyle P.;Hong Fei;Vasserot Alain Philippe;Lo Wing-Sze;Watkins Jeffry Dean;Quinn Cheryl L.;Mendlein John D. |
分类号 |
C12N9/00;A61K38/53;C07K16/40 |
主分类号 |
C12N9/00 |
代理机构 |
Cooley LLP |
代理人 |
Cooley LLP |
主权项 |
1. A therapeutic composition, comprising an isolated threonyl-tRNA synthetase (TRS) polypeptide of up to 340 amino acids in length that comprises SEQ ID NO:14 or an amino acid sequence that is at least 95% identical to SEQ ID NO:14, wherein the polypeptide has an extracellular signaling activity and a solubility of at least about 5 mg/mL, and wherein the composition has a purity of at least about 95% on a protein basis and less than about 10 EU endotoxin/mg protein. |
地址 |
San Diego CA US |