| 摘要 |
Basic esters of fatty alcohols of the general formula: R1-O—CO-A or pharmaceutically acceptable salts thereof, wherein R1 is C12-C24 alkyl or C10-C24 alkenyl, and A is a residue containing at least one acyclic or cyclic amino group and/or at least one heteroaromatic ring containing a tertiary or quaternary nitrogen atom, are anti-inflammatory and immunomodulatory agents, useful in the treatment of immunologically-mediated inflammation, as adjuvants for antigens involved in both cellular and humoral responses. |
| 主权项 |
1. A compound of the general formula:
R1-O—CO-A wherein
R1 is C20-C24 alkyl or C16-C18 alkenyl and A is a residue of the formula: wherein R2 is H, C1-C6 alkyl, aryl, or aralkyl, wherein any aryl moiety may be unsubstituted or substituted by nitro, cyano, halo, hydroxy, NR6R7, or CR8R8NR6R7; R3 is H, a pair of electrons, or C1-C6 alkyl; R4 and R5 each is H or each is C1-C6 alkyl, or R4 and R5 together with the nitrogen atom to which they are attached form a 5-7 membered saturated ring optionally interrupted by an oxygen atom or by a nitrogen atom optionally substituted by C1-C6 alkyl; and R6, R7 and R8 each independently is H or C1-C6 alkyl,wherein: when R3 is a pair of electrons and R4 and R5 are each H, then R2 is C5-C6 alkyl, aryl, or aralkyl, wherein any aryl moiety may be unsubstituted or substituted by nitro, cyano, halo, NR6R7, or CR8R8NR6R7; and pharmaceutically acceptable salts thereof. |
