| 发明名称 | Lisofylline analogs and methods for use | ||
| 摘要 | The present invention provides analogs of a Lysofylline (LSF), and synthetic methods for the preparation of such analogs. The have the active side chain moiety (5-R-hydroxyhexyl) of LSF and can have greater potency and oral bioavailability than LSF. | ||
| 申请公布号 | US8987321(B2) | 申请公布日期 | 2015.03.24 |
| 申请号 | US201313928691 | 申请日期 | 2013.06.27 |
| 申请人 | University of Virginia Patent Foundation | 发明人 | MacDonald Timothy L.;Nadler Jerry L.;Cui Peng |
| 分类号 | A61K31/405;C07D209/08;A61K31/538;C07C215/68;C07C219/32;C07D209/80;C07D221/08;C07D223/22;C07D241/08;C07D241/18;C07D249/12;C07D253/04;C07D265/26;C07D265/36;C07D265/38;C07D275/04;C07D279/22;C07D487/04;A61K31/404;A61K31/4196;A61K31/495;A61K31/502;A61K31/53 | 主分类号 | A61K31/405 |
| 代理机构 | J.A. Lindeman & Co., PLLC | 代理人 | J.A. Lindeman & Co., PLLC |
| 主权项 | 1. A compound having formula II: wherein R1 is hydrogen or a group having the formula —C(═O)R3, wherein R3 is hydrogen or lower alkyl, and R2 is and n is 1 or 2; or a pharmaceutically acceptable salt thereof. | ||
| 地址 | Charlottesville VA US | ||