| 主权项 |
1. A compound of Formula (E):wherein:
A and B are each nitrogen, wherein A and B are bonded together to form a five-membered heteroaryl ring; L1 is a bond, C1-C6alkyl, or C1-C6heteroalkyl; L2 is C1-C6alkyl or C1-C6heteroalkyl; R1 is hydrogen, halogen, —CF3, —OR8, —N(R8)2, —C(═O)R8, —C(═O)OR8, —C(═O)N(R8)2, —C(═N—OH)R8, —C(═S)N(R8)2, —C(═CH2)CH3, or —C(═O)OCH2SCH3; R2 is —C(═O)OR9, —C(═O)N(R9)2, —NR10C(═O)R9, —C(═N—OH)R9, —C(═S)N(R9)2, or —C(═O)OCH2SCH3; R3 is hydrogen, halogen, C1-C6alkyl, or C1-C6haloalkyl; R4 is aryl or heteroaryl; wherein aryl or heteroaryl is substituted with at least one R11; each R8, each R9, and each R10 are each independently hydrogen, C1-C6alkyl, C1-C6heteroalkyl, —C1-C6alkyl-aryl, aryl, or heteroaryl; each R11 is independently halogen, nitro, —OR10, —N(R10)2, —CN, —C(═O)R10, —C(═O)OR10, —C(═O)N(R10)2, —NR10C(═O)R10, NR10SO2R10, —SOR10, —SO2R10, —SO2N(R10)2, —C(═O)OCH2SCH3, C1-C6alkyl, C3-C8cycloalkyl, C1-C6haloalkyl, C1-C6heteroalkyl, —C1-C6alkyl-aryl, optionally substituted aryl, or optionally substituted heteroaryl;or a pharmaceutically acceptable salt or pharmaceutically acceptable solvate thereof. |
