Substituted triazolyl piperazine and triazolyl piperidine derivatives as gamma secretase modulators

摘要

The present invention is concerned with novel substituted triazolyl piperazine and triazolyl piperidine derivatives of Formula (I);
wherein R1, R2, R3, R4a, R4b, R5, X, Y1, Y2, L1, and L2 have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

主权项

1. A compound of Formula (I)or a stereoisomeric form thereof, wherein
R1 and R2 independently are selected from the group consisting of hydrogen, halo, C1-4 alkyl, C1-4 alkyloxy, C1-4 alkyl substituted with one or more halo substituents, and C1-4 alkyloxy substituted with one or more halo sub stituents; L1 is NR6, O, carbonyl or a covalent bond; wherein R6 is hydrogen or C1-4 alkyl; R3 represents C1-4 alkyl; R4a and R4b independently are selected from the group consisting of hydrogen and C1-4 alkyl; X is N or CH; L2 is O, CH2 or a covalent bond; provided that when L2 is O, then X is CH; R5 is hydrogen or C1-4 alkyl; Y1 is CH or N; Y2 is CR7 or N; wherein R7 represents H or C1-4 alkyloxy; or a pharmaceutically acceptable addition salt or a hydrate thereof.