Compositions, devices, and methods related to prostate-specific membrane antigen

摘要

PSMA ligands, compositions, and methods therefore are disclosed where the ligand is a peptide having the sequence X1X2CVEVX3QNSCX4X5 where X1-X5 are independently a natural or non-natural amino acid or a peptide having the sequence CALCEFLG [SEQ ID NO: 1]. Especially preferred aspects include diagnostic reagents for detection and/or quantification of PSMA in a sample, therapeutic reagents, and diagnostic imaging reagents.

主权项

1. A recombinantly produced or synthetically produced PSMA binding reagent comprising a PSMA binding peptide having the sequence X1X2CVEVX3QNSCX4X5 [SEQ ID NO: 2], wherein X1 to X5 are independently a natural amino acid or a non-natural amino acid, or having the sequence CALCEFLG [SEQ ID NO: 1] covalently linked either directly or indirectly to one or more moieties selected from the group consisting of an imaging contrast agent, an enzyme, a toxin, a detectable label, a protecting group, a therapeutic moiety, and a solid phase.