Multilayered silk scaffolds for meniscus tissue engineering

摘要

Provided herein is a biocompatible implant for meniscus tissue engineering. Particularly, the biocompatible implant comprises a multi-layered crescent-shaped silk fibroin scaffold, in which each layer comprises distinct pore size and/or pore orientation, e.g., to mimic native meniscus complex architecture. Accordingly, the biocompatible implant can be used for repairing any meniscal defect or promoting meniscal regeneration in a subject.

主权项

1. A biocompatible implant comprising: a silk fibroin scaffold having at least a first layer and a second layer, wherein the first layer is characterized as having a pore size distribution between about 100 and about 1,000 microns in diameter and comprises two sub-layers, wherein a first sub-layer has a larger pore size distribution than a second sub-layer, and the second layer comprises laminar channels.