A method for decreasing the immunogenicity of antibody variable domains is disclosed.
申请公布号
US2015080555(A1)
申请公布日期
2015.03.19
申请号
US201414308936
申请日期
2014.06.19
申请人
ESBATech, an Alcon Biomedical Research Unit LLC
发明人
Urech David;Borras Leonardo Jose
分类号
C07K16/42
主分类号
C07K16/42
代理机构
代理人
主权项
1. An antibody variable domain comprising a variable light chain having a substitution at position 99, 101 and/or 148 (Aho numbering), and a variable heavy chain having a substitution at position 12, 97, 98, 99, 103, and/or 144 (AHo numbering).
