| 发明名称 |
Nanoparticulate Compositions for Targeted Delivery of Acid Labile, Lipophilic Prodrugs of Cancer Chemotherapeutics and Their Preparation |
| 摘要 |
In one embodiment, the present application discloses synthetic LDL nanoparticles comprising mixtures of components selected from the group consisting of phospholipids, triglycerides, cholesterol ester and free cholesterol; optionally further comprising an agent selected from the group consisting of natural antioxidants, ubiquinol and vitamin E, and methods for preparing the synthetic nanoparticles. The disclosed synthetic LDL nanoparticles are capable of selectively delivering lipophilic drugs and prodrugs to cellular targets expressing LDL receptors after intra venous injection. |
| 申请公布号 |
US2015079189(A1) |
申请公布日期 |
2015.03.19 |
| 申请号 |
US201414485713 |
申请日期 |
2014.09.13 |
| 申请人 |
Arbor Therapeutics, LLC |
发明人 |
McChesney James D.;Nikoulin Igor;Bannister Steve J.;Rodenburg Douglas L. |
| 分类号 |
A61K9/127;A61K31/337;A61K31/4745;A61K31/427;A61K31/575;A61K31/366;A61K31/704;A61K31/7056;A61K31/7076;A61K31/7068;A61K31/365;A61K31/5685;A61K31/475;A61K47/48;A61K45/06 |
主分类号 |
A61K9/127 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A stable, synthetic low density lipoprotein (LDL) nanoparticle comprising:
a) a lipophilic anti-cancer agent with a logP greater than 4.0; b) phospholipids (PL); and c) triglycerides (TG); wherein the LDL nanoparticle has a particle size of 40-80 nm. |
| 地址 |
Etta MS US |
