发明名称 |
LONG-ACTING COAGULATION FACTORS AND METHODS OF PRODUCING SAME |
摘要 |
Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotropin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed. |
申请公布号 |
US2015079063(A1) |
申请公布日期 |
2015.03.19 |
申请号 |
US201414274061 |
申请日期 |
2014.05.09 |
申请人 |
OPKO Biologics Ltd. |
发明人 |
FIMA Udi Eyal;Hart Gili |
分类号 |
C12N9/96;C07K14/59;C12N9/64 |
主分类号 |
C12N9/96 |
代理机构 |
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代理人 |
|
主权项 |
1. A CTP-modified polypeptide consisting of a coagulation factor and three chorionic gonadotropin carboxy terminal peptides (CTPs) attached to the carboxy terminus of said coagulation factor. |
地址 |
Nes Ziona IL |