发明名称 |
REPLICATION-COMPETENT VESICULAR STOMATITIS VIRUSES |
摘要 |
This document provides methods and materials related to vesicular stomatitis viruses. For example, replication-competent vesicular stomatitis viruses, nucleic acid molecules encoding replication-competent vesicular stomatitis viruses, methods for making replication-competent vesicular stomatitis viruses, and methods for using replication-competent vesicular stomatitis viruses to treat cancer or infectious diseases are provided. |
申请公布号 |
US2015079037(A1) |
申请公布日期 |
2015.03.19 |
申请号 |
US201314395388 |
申请日期 |
2013.03.13 |
申请人 |
Mayo Foundation for Medical Education and Research |
发明人 |
Peng Kah-Whye;Russell Stephen James;Breton Camilo Ayala |
分类号 |
A61K35/76;C12N7/00 |
主分类号 |
A61K35/76 |
代理机构 |
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代理人 |
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主权项 |
1. A replication-competent vesicular stomatitis virus comprising an RNA molecule, wherein said RNA molecule comprises a nucleic acid sequence that is a template for a positive sense transcript encoding a VSV N polypeptide, a nucleic acid sequence that is a template for a positive sense transcript encoding a VSV P polypeptide, a nucleic acid sequence that is a template for a positive sense transcript encoding a VSV M polypeptide, a nucleic acid sequence that is a template for a positive sense transcript encoding a Paramyxovirus F polypeptide, a nucleic acid sequence that is a template for a positive sense transcript encoding a Paramyxovirus H polypeptide, and a nucleic acid sequence that is a template for a positive sense transcript encoding a VSV L polypeptide, wherein said RNA molecule lacks a nucleic acid sequence that is a template for a positive sense transcript encoding a functional VSV G polypeptide. |
地址 |
Rochester MN US |