发明名称 |
Therapeutic DLL4 binding proteins |
摘要 |
<p>DLL4 binding proteins are described herein, including antibodies, CDR-grafted antibodies, humanized antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL4 and/or VEGF activity. The DLL4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis.</p> |
申请公布号 |
AU2011223919(B2) |
申请公布日期 |
2015.03.19 |
申请号 |
AU20110223919 |
申请日期 |
2011.02.28 |
申请人 |
ABBVIE INC. |
发明人 |
LI, YINGCHUN;GU, JIJIE JAMES;MORGAN-LAPPE, SUSAN;CHEN, MINGJIU;HSIEH, CHUNG-MING |
分类号 |
C07K16/00;A61K39/395;A61K49/00;A61P9/00;A61P17/06;A61P25/28;A61P35/00;A61P43/00;C07H21/00;C07K16/18;C07K17/00;C12N1/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/96;C12N15/63;C12P21/00 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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