发明名称 EPITOPE FOR MEDICAL TREATMENT AND USE FOR THE SAME
摘要 PROBLEM TO BE SOLVED: To develop a test to be used for diagnosis of Celiac disease in an initial stage.SOLUTION: Disclosed is a method for diagnosing Celiac disease or susceptibility to Celiac disease in a sample obtained from an individual including: bringing a sample from an individual into contact with at least one agent selected from: (i) peptide comprising at least one epitope comprising a sequence selected from a group comprising sequence numbers: 18, 20-22, 31-36, 40-44, and 46 and their equivalents; (ii) an analogue of (i) which is recognized by a T cell receptor that recognizes (i), and which is not more than 50 amino acids in length; and (iii) peptide comprising at least one epitope comprising a sequence selected from a sequence number: 1 and a sequence number: 2 in addition to an agent arbitrarily selected from (i) and (ii); and determining in vitro whether or not T cells in the sample recognize the agent, while recognition by the T cells indicating that the individual has or is susceptible to Celiac disease.
申请公布号 JP2015052599(A) 申请公布日期 2015.03.19
申请号 JP20140198382 申请日期 2014.09.29
申请人 ISIS INNOVATION LTD 发明人 ANDERSON ROBERT PAUL;ADRIAN VIVIAN SIMTON HILL;JEWELL DEREK PARRY
分类号 G01N33/53;A01K67/027;A61K38/00;A61K39/395;A61K45/00;A61P1/00;A61P3/00;C07K14/415;C07K14/705;C12N1/21;C12N5/10;C12N15/09 主分类号 G01N33/53
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