HEPATOCYTES IN CO-CULTURE AND USES THEREOF

摘要

The present disclosure provides a human hepatocyte co-culture which maintains the phenotype of cells from human donors with diabetes, and methods of using same. The hepatocyte co-culture system provides an in vitro model in which both cell viability and phenotype are maintained for extended periods relative to primary human hepatocyte monocultures, and is used in methods for high throughput screening and evaluation of drug candidates, and kits for performing such testing.

主权项

1. A composition comprising a population of hepatocytes and at least one non-parenchymal cell population in co-culture, wherein the hepatocytes are obtained from one or more human donors suffering from a metabolic disorder of the liver.