| 发明名称 |
MENA AND ALPHA5 INTEGRIN INTERACTION |
| 摘要 |
Methods are provided for treating invasion of a tumor or metastasis of a tumor in a subject comprising administering to the subject an agent which inhibits the interaction of Mena with an alpha5 integrin. Assays for identifying agents that inhibit interaction of Mena with an alpha5 integrin are also provided. |
| 申请公布号 |
US2015079113(A1) |
申请公布日期 |
2015.03.19 |
| 申请号 |
US201314395617 |
申请日期 |
2013.05.09 |
| 申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
发明人 |
Gertler Frank B.;Gupton Stephanie;Riquelme Daisy;Hughes-Alford Shannon K.;Oudin Madeleine J. |
| 分类号 |
C07K16/18;C12N15/115;G01N33/50;C07K2/00 |
主分类号 |
C07K16/18 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of treating invasion of a tumor in a subject or inhibiting metastasis of a tumor in a subject comprising administering to the subject an agent which inhibits the interaction of a Mena with an alpha5 integrin in an amount effective to treat invasion or inhibit metastasis of a tumor. |
| 地址 |
Cambridge MA US |
