REGENERATION OF INNER EAR CELLS

摘要

The invention provides compositions and methods for treating or preventing hearing loss in a subject. The method comprises administering to the subject in need thereof, at least Myc or an agent that increases the expression of Myc in an inner ear organ, or associated neural structures, of the subject so as to treat or prevent the hearing loss.

主权项

1. A method for stimulating the formation of an inner ear sensory hair cell from an inner ear supporting cell, the method comprising contacting an inner ear supporting cell with an effective amount of an agent that is capable of inducing the expression of a Myc family protein in the supporting cell, wherein expression of the Myc family protein in the inner ear supporting cell can stimulate the formation of an inner ear sensory hair cell.