A LACTOCOCCAL BICISTRONIC VECTOR SYSTEM FOR GENE DELIVERY AND METHOD OF PREPARATION THEREOF

摘要

The present invention provides a bicistronic vector system based on Lactococcus lactis plasmid DNA into which an eukaryotic promoter, a first gene to be transcribed by the promoter, internal ribosome entry (IRES), a second gene to be transcribed by IRES and transcription terminator signal are incorporated in said order downstream of each other. The invention also provides a method of preparation of such vector.