PROCESS FOR THE PRODUCTION OF HIGH-DENSITY MESALAMINE

摘要

The present invention relates, in a first aspect, to a process for the production of mesalamine having a bulk density greater than or equal to 0.30 g/ml conveniently free of solvents wherein the crystallisation is obtained by slowly pouring optionally in two or more portions, an acid solution of mesalamine hydrochloride in an aqueous solution buffered with a buffer system based on acetic acid or sodium acetate.