发明名称 |
TARGETED THERAPEUTICS |
摘要 |
The present invention provides pharmacological compounds including an effector moiety conjugated to a binding moiety that directs the effector moiety to a biological target of interest. Likewise, the present invention provides compositions, kits, and methods (e.g., therapeutic, diagnostic, and imaging) including the compounds. The compounds can be described as a protein interacting binding moiety-drug conjugate (SDC-TRAP) compounds, which include a protein interacting binding moiety and an effector moiety. For example, in certain embodiments directed to treating cancer, the SDC-TRAP can include an Hsp90 inhibitor conjugated to a cytotoxic agent as the effector moiety. |
申请公布号 |
CA2923829(A1) |
申请公布日期 |
2015.03.19 |
申请号 |
CA20142923829 |
申请日期 |
2014.09.10 |
申请人 |
SYNTA PHARMACEUTICALS CORP. |
发明人 |
CHIMMANAMADA, DINESH U.;YING, WEIWEN;ZHANG, JUNYI;KOWALCZYK-PRZEWLOKA, TERESA;JIANG, JUN;OSMAN, SAMI;LU, GENLIANG;VUTUKURI, DHARMA;LOCH, JAMES;CHEN, SHOUJUN |
分类号 |
A61K31/52;A61K47/48;A61K49/00;A61P11/06;A61P17/00;A61P35/00 |
主分类号 |
A61K31/52 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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