THERAPY FOR KIDNEY DISEASE AND/OR HEART FAILURE BY INTRADERMAL INFUSION

摘要

Intradermal delivery devices, systems and methods thereof for the administration of a natriuretic or chimeric peptide are described. The described delivery devices, systems and methods provide for the treatment of pathological conditions such as kidney disease alone, heart failure alone, concomitant kidney disease and heart failure, or cardiorenal syndrome by delivery of a natriuretic or chimeric peptide through a microneedle array using a delivery pump. The described delivery devices, systems and methods can provide for greater availability of a natriuretic or chimeric peptide and improved pharmacokinetics.

主权项

1. An intradermal delivery device, comprising:
a drug provisioning component having a pumping apparatus to administer a therapeutically effective amount of a therapeutic composition from a reservoir; a microneedle array having a substrate with plural microneedles projecting from a surface of the substrate, the microneedles in fluid communication with the reservoir and an intra-substrate space; a catheter for transporting the composition from the reservoir to the intra-substrate space; a first pressure sensor for sensing a pressure within the catheter; and a controller for controlling a pumping rate of the pump and for monitoring a pressure within the catheter to determine if flow through the microneedle array is within an expected range.