COMPOSITIONS AND METHODS FOR USE OF HIGH MOLECULAR WEIGHT HYALURONIC ACID FOR CANCER THERAPY

摘要

The disclosure provides compositions and methods for treating or preventing cancer in a subject in need thereof. Specifically, the disclosure provides a composition comprising high molecular weight hyaluronic acid (HMW-HA) or an isolated nucleic acid encoding mole-rat hyaluronic acid synthase 2 (HAS2), and methods for increasing the level of HMW-HA in a subject, thereby treating or preventing cancer.