| 发明名称 |
METHOD FOR SELECTIVELY INHIBITING ACAT1 IN THE TREATMENT OF NEURODEGENERATIVE DISEASES |
| 摘要 |
The present invention features methods for stimulating clearance of misfolded or aggregated proteins or peptides in microglia or neurons, and treating neurodegenerative diseases associated with such pathology in brain by selectively inhibiting the expression or activity of Acyl-CoA:Cholesterol Acyltransferase 1, but not Acyl-CoA:Cholesterol Acyltransferase 2. |
| 申请公布号 |
US2015079161(A1) |
申请公布日期 |
2015.03.19 |
| 申请号 |
US201414550025 |
申请日期 |
2014.11.21 |
| 申请人 |
Trustees of Dartmouth College |
发明人 |
Chang Ta-Yuan;Chang Catherine C.Y.;Shibuya Yohei;Niu Zhaoyang |
| 分类号 |
C12N15/113;A61K31/255;A61K31/44;A61K35/76;C12N7/00 |
主分类号 |
C12N15/113 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A method for stimulating clearance of misfolded or aggregated proteins and peptides in microglia or neurons comprising administering to a subject in need thereof an Acyl-CoA:Cholesterol Acyltransferase 1-selective inhibitor thereby stimulating clearance of the misfolded or aggregated proteins and peptides in microglia or neurons in the subject. |
| 地址 |
Hanover NH US |
