SYSTEM AND METHOD FOR PRESENTING LARGE DNA MOLECULES FOR ANALYSIS
摘要
<p>Systems and methods for presenting nucleic acid molecules for analysis are provided. The nucleic acid molecules have a central portion that is contained within a nanoslit. The nanoslit contains an ionic buffer. The nucleic acid molecule has a contour length that is greater than a nanoslit length of the nanoslit. An ionic strength of the ionic buffer and electrostatic or hydrodynamic properties of the nanoslit and the nucleic acid molecule combining to provide a summed Debye length that is greater than or equal to the smallest physical dimension of the nanoslit.</p>
申请公布号
WO2015038953(A1)
申请公布日期
2015.03.19
申请号
WO2014US55484
申请日期
2014.09.12
申请人
WISCONSIN ALUMNI RESEARCH FOUNDATION;UNIVERSITY OF LEIDEN;UNIVERSITY OF CHICAGO