| 发明名称 |
Cell Modified in the Expression of a Nucleotide Sugar Transporter |
| 摘要 |
The present invention provides for a genetically modified eukaryotic host cell comprising (a) a gene encoding a first nucleotide sugar transporter (NST) operably linked to a promoter, wherein the gene and/or the promoter is heterologous to the cell, and/or (b) a native gene encoding a second NTS is disrupted and/or a promoter of the native gene is disrupted. Such modified cells can be altered in the production of polysaccharide and/or glycopeptides. The present invention also provides for methods of making or using such modified cells. |
| 申请公布号 |
US2015082494(A1) |
申请公布日期 |
2015.03.19 |
| 申请号 |
US201414306183 |
申请日期 |
2014.06.16 |
| 申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
Scheller Henrik Vibe;Rautengarten Carsten;Ebert Berit;Heazlewood Joshua L. |
| 分类号 |
C12N15/82 |
主分类号 |
C12N15/82 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A genetically modified eukaryotic host cell comprising (a) a gene encoding a first nucleotide sugar transporter (NST) operably linked to a promoter, wherein the gene and/or the promoter is heterologous to the cell, and/or (b) a native gene encoding a second NTS is disrupted and/or a promoter of the native gene is disrupted. |
| 地址 |
OAKLAND CA US |
