发明名称 |
COMPOSITIONS USEFUL FOR TREATING HERPES SIMPLEX KERATITIS, AND METHODS USING SAME |
摘要 |
The present invention relates generally to compositions and methods for treating diseases and disorders caused by herpes simplex virus type 1, including herpes simplex keratitis, in a subject. In certain embodiments, the compositions of the present invention comprise an ATM inhibitor and an anti-herpetic agent. In other embodiments, the compositions comprise a Chk2 inhibitor and an anti-herpetic agent. In yet other embodiments, the compositions comprise a Chk2 inhibitor and an ATM inhibitor, and optionally an anti-herpetic agent. |
申请公布号 |
US2015080390(A1) |
申请公布日期 |
2015.03.19 |
申请号 |
US201414488980 |
申请日期 |
2014.09.17 |
申请人 |
Drexel University |
发明人 |
Clifford Jane E.;Alekseev Oleg;Jennings Stephen R. |
分类号 |
A61K31/5377;A61K31/522 |
主分类号 |
A61K31/5377 |
代理机构 |
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代理人 |
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主权项 |
1. A composition comprising an anti-herpetic agent and at least one inhibitor selected from the group consisting of an ATM inhibitor, a Chk2 inhibitor, and a salt, solvate or N-oxide thereof, wherein the composition treats or prevents herpes simplex keratitis in a subject in need thereof. |
地址 |
Philadelphia PA US |